MK-677 Powder (Istobal/Nutrobal)

Brief Intro

MK-677 Powder (also known as Ibutamoren, Istobal, or Nutrobal) is a potent, orally active growth hormone secretagogue that mimics the action of the hormone ghrelin by binding to ghrelin receptors (GHSR) in the brain. It stimulates the release of growth hormone (GH) and insulin-like growth factor 1 (IGF-1), promoting increased muscle mass, improved bone density, enhanced sleep quality, and potential anti-aging benefits. MK-677 is widely researched for its ability to support muscle growth, reduce muscle wasting, and improve overall metabolic health. This powder is intended exclusively for scientific research and analytical purposes and is not for human consumption.

Chemical Structure / Physical Properties

• Chemical Name: Ibutamoren mesylate (MK-677)

• Molecular Formula: C28H40N4O8S2 (mesylate salt)

• Molecular Weight: Approximately 624.77 g/mol (mesylate salt)

• CAS Number: 159752-10-0

• Purity: Typically ≥98%

• Form: White to beige crystalline powder

• Melting Point: 164–170 °C

• Solubility: Soluble in water (~5 mg/mL), DMSO, and ethanol

• Storage: Store at 2–8 °C or -20 °C for long-term stability

Pharmacology and Mechanism of Action

MK-677 acts as a selective agonist of the ghrelin receptor (GHSR), stimulating the pituitary gland to release growth hormone and subsequently increasing IGF-1 levels without affecting cortisol. It promotes sustained activation of the GH-IGF-1 axis, leading to enhanced muscle protein synthesis, improved bone mineral density, and accelerated tissue regeneration. MK-677 also influences appetite regulation, sleep quality, and cognitive functions through its action on ghrelin receptors in brain regions controlling these processes.

Intended Use

MK-677 Powder is intended strictly for laboratory research, including pharmacological, biochemical, and metabolic studies related to growth hormone secretion, muscle growth, bone health, aging, and neurobiology. It is not for human consumption or clinical use.

Packaging & Shipping

MK-677 Powder is securely packaged and shipped discreetly with tracking. Typical delivery times range from 24 to 72 hours within the USA and up to 5 days internationally, depending on destination. Shipping fees are calculated at checkout based on location.

Legal & Compliance Disclaimer

All products are sold for research purposes only and are not intended for human consumption. Customers must verify the legal status of MK-677 in their jurisdiction before ordering. The vendor reserves the right to accept or decline orders based on intended use.

Dosage and use

A daily dose of ibutamoren generally contains 25mg. However, a small amount of powder will also have an effect. Therefore, a lower dose of 5 to 10mg is also sufficient. Use this SARM for 8 to 12 weeks.

Please note that this SARM has some side effects at doses above 25 mg. Increased appetite and lethargy (sickly sleep) may occur with the use of ibutamoren. Take this into account when timing your intake! In order to reduce the side effects, it is recommended to build up the use of this SARM gradually.

Next lvl muscle MK-677 ibutamoren can be used for both men and women and can be combined with other SARMs and prohormones. This SARM can also be used during bulking and cutting weight.

What are SARMs?

SARMs are Selective Androgen Receptor Modulators. In simple terms, these substances can tell your cells to produce more muscle mass or break down more fat, for example. Each SARM has a different effect, allowing you to achieve aesthetic and physical goals in a very targeted way. And all that without suffering unpleasant side effects such as hair loss, acne and liver damage.

Please note: all information about these research chemicals and the research chemicals themselves are for educational and research purposes only. These products are not a supplement and are not suitable for human consumption.