2-METHYL-AP-237 HCl Powder

Brief Intro

2-METHYL-AP-237 HCl Powder is a synthetic opioid analgesic belonging to the acyl piperazine class. It is structurally related to AP-237 (buccinazine) and is recognized for its potent opioid receptor agonist activity. 2-METHYL-AP-237 has emerged in recent years as a novel psychoactive substance (NPS) and is primarily used in scientific and forensic research to study opioid pharmacology, metabolism, and toxicology. This compound is strictly intended for research purposes and is not for human consumption.

Chemical Structure / Physical Properties

• Chemical Name: 1-[2-methyl-4-(3-phenyl-2-propen-1-yl)-1-piperazinyl]-1-butanone hydrochloride

• Synonyms: 2-methyl AP-237, 2-methyl buccinazine

• Molecular Formula: C18H26N2O·HCl

• Molecular Weight: 322.9 g/mol (hydrochloride salt)

• CAS Number: 98608-59-4

• Appearance: Odorless, white crystalline powder

• Melting Point: 211–213 °C (hydrochloride salt)

• Solubility: Soluble in DMF (10 mg/mL), DMSO (15 mg/mL), ethanol (30 mg/mL), PBS pH 7.2 (10 mg/mL)

• Storage: Store at -20°C, protected from light and moisture

• Purity: Typically >91% by 1H NMR in analytical samples

Pharmacology and Mechanism of Action

2-METHYL-AP-237 acts as a potent opioid receptor agonist, producing analgesic effects similar to other synthetic opioids. It binds to mu-opioid receptors, leading to effects such as pain relief, sedation, and, at higher doses, respiratory depression. The compound is metabolized in the liver, with phase I metabolites including monohydroxylated derivatives. There are no published clinical studies, but animal and in vitro data support its opioid activity. Reports indicate a risk of caustic irritation with certain routes of administration and a potential for toxicity at high doses.

Intended Use

2-METHYL-AP-237 HCl Powder is intended strictly for laboratory research, forensic analysis, and toxicological studies related to synthetic opioids and acyl piperazine pharmacology. It is not for human or veterinary consumption.

Packaging & Shipping

The powder is securely packaged and shipped discreetly with tracking. Typical delivery times range from 24 to 72 hours within the USA and up to 5 days internationally, depending on destination. Shipping fees are calculated at checkout based on location.

Legal & Compliance Disclaimer

All products are sold for research purposes only and are not intended for human consumption. Customers must verify the legal status of 2-METHYL-AP-237 in their jurisdiction before ordering. The vendor reserves the right to accept or decline orders based on intended use.